Transcriptional regulator PRDM12 is essential for human pain perception as originally seen in Nature Genetics
Pain is terribly interesting. It’s terrible, but necessary to keep us safe. Congenital insensitivity to pain encompasses several genetic mutations. In the PRDM12 mutation, the nociceptor nerves simply do not form. The SCN9A mutation causes the sodium channel Nav1.7 to not form, which damages the nerves ability to transmit the pain signals.
Not being able to feel pain sounds like pure bliss, but when I was in undergrad, I was assigned to watch the documentary A Life Without Pain. Here is a snip from that.
So now you can thank God you can feel pain, even if it’s got you lame.