ALS Gene Mutation

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics as originally seen in Neuron All that science-y gobbly guck basically means that researchers have found what’s going bad in ALS. They’ve flipped through the genes of a family that has ALS and also frontotemporal dementia (which sometimes accompanies ALS) … Continue reading ALS Gene Mutation

Too Little and Too Much Movement: How to Assess and Describe (Part 7)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology Here are the obligatory hotlinks to the other posts in the series on this article: #1, #2, #3, #4, #5 and #6. Today we have the final installment in this series discussing the above article on assessing and describing movement disorders. This … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 7)

Too Little and Too Much Movement: How to Assess and Describe (Part 5)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology Here are the obligatory hotlinks to the other posts in the series on this article: #1, #2, #3, and #4. We continue on to non-jerky hyperkinetic syndromes. Our first stop is tremors! For those that thought (hoped? prayed?) you’d never have to … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 5)

Too Little and Too Much Movement: How to Assess and Describe (Part 4)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology Here is the fourth installment in the series on the above article. If you’re wondering what is going on in this series, you can find installment #1, #2, and #3 by clicking on those hotlinks and catch yourself up! It’s a really … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 4)

Too Little and Too Much Movement: How to Assess and Describe (Part 3)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology We’ve been working through the above article in a series of posts here and here thus far. This will be installment #3 on chorea. Here’s a video of some chorea in Huntington’s to get a visual.   And here’s a visual of … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 3)

Too Little and Too Much Movement: How to Assess and Describe (Part 2)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology We continue on with this article that is describing terminology related to movement disorders. Here is a little more info about the asterixis. In this video in the gait session starting about 1:45, you can see where the subject’s path veers off … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 2)

Too Little and Too Much Movement: How to Assess and Describe (Part 1)

The Clinical Approach to Movement Disorders as originally seen in Nature Reviews Neurology Ran across some other folks talking about this article. The article is really good with lots of good details to pack away in the neuro toolbox. It’s so good, that I don’t think I could do it all justice in just one post (not … Continue reading Too Little and Too Much Movement: How to Assess and Describe (Part 1)

Forced Vital Capacity in ALS

Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population as originally seen in The Journal of Neurology, Neurosurgery and Psychiatry Last week were talking about outcome measures in ALS. In looking at those, we found forced vital capacity (FVC) was an important one to keep track of, … Continue reading Forced Vital Capacity in ALS